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| Date | Game# | Record | ConfRank | LgRank | Opp | Result | Goalie | Goals |
| Oct 5,2005 | 1 | 0-1-0 | 14 | 28 | vs MON | L 1-2 | Raycroft | P. Bergeron |
| Oct 7,2005 | 2 | 0-2-0 | 15 | 30 | at BUF | L 1-4 | Raycroft | G. Murray |
| Oct 8,2005 | 3 | 1-2-0 | 13 | 26 | at PIT | W 7-6 | Toivonen | G. Murray [2], P. Leahy, T. Green, P. Bergeron, B. Boyes, S. Samsonov |
| Oct 10,2005 | 4 | 2-2-0 | 9 | 14 | at TB | W 4-2 | Raycroft | T. Green, B. Leetch, B. Isbister, P. Axelsson |
| Oct 13,2005 | 5 | 3-2-0 | 6 | 8 | at FLA | W 5-2 | Raycroft | P. Bergeron, G. Murray, B. Isbister, T. Fitzgerald, P. Axelsson |
| Oct 15,2005 | 6 | 3-3-0 | 10 | 17 | at OTT | L 1-5 | Raycroft | P. Leahy |
| Oct 18,2005 | 7 | 3-4-0 | 12 | 21 | at MON | L 3-4 | Raycroft | N. Boynton, B. Leetch, P. Axelsson |
| Oct 20,2005 | 8 | 3-5-0 | 13 | 23 | vs BUF | L 3-4 | Toivonen | S. Samsonov [2], P. Axelsson |
| Oct 22,2005 | 9 | 4-5-0 | 12 | 19 | vs PIT | W 6-3 | Raycroft | D. Scatchard [2], J. Thornton [2], G. Murray, S. Samsonov |
| Oct 24,2005 | 10 | 4-5-1 | 9 | 15 | at TOR | OTL 4-5 | Raycroft | P. Leahy, G. Murray, B. Boyes, I. Moran |
| Oct 26,2005 | 11 | 4-5-2 | 10 | 17 | at CAR | OTL 3-4 | Raycroft | B. Boyes, B. Leetch, S. Samsonov |
| Oct 27,2005 | 12 | 5-5-2 | 9 | 14 | vs TOR | W 2-1 | Toivonen | J. Slegr, S. Samsonov |
| Oct 29,2005 | 13 | 5-5-3 | 8 | 16 | vs NJ | SOL 4-5 | Toivonen | G. Murray, J. Thornton, S. Samsonov, P. Axelsson |
| Date | Game# | Record | ConfRank | LgRank | Opp | Result | Goalie | Goals |
| Nov 1,2005 | 14 | 5-5-4 | 9 | 16 | at NYI | OTL 3-4 | Toivonen | N. Boynton, D. Scatchard, J. Thornton |
| Nov 3,2005 | 15 | 6-5-4 | 6 | 11 | vs FLA | W 4-1 | Toivonen | J. Slegr, T. Green, G. Murray, B. Boyes |
| Nov 5,2005 | 16 | 7-5-4 | 5 | 9 | vs PIT | W 6-3 | Toivonen | J. Slegr [2], J. Thornton [2], N. Boynton, P. Bergeron |
| Nov 8,2005 | 17 | 7-5-5 | 6 | 12 | at PHI | OTL 3-4 | Toivonen | J. Thornton, S. McEachern, S. Samsonov |
| Nov 10,2005 | 18 | 7-6-5 | 6 | 13 | vs OTT | L 2-5 | Raycroft | G. Murray, B. Boyes |
| Nov 12,2005 | 19 | 7-7-5 | 7 | 16 | at NYI | L 2-5 | Raycroft | D. Scatchard, S. Samsonov |
| Nov 17,2005 | 20 | 7-8-5 | 10 | 19 | vs TOR | L 1-4 | Raycroft | B. Isbister |
| Nov 19,2005 | 21 | 7-9-5 | 11 | 22 | vs BUF | L 2-3 | Raycroft | J. Thornton, P. Axelsson |
| Nov 20,2005 | 22 | 7-10-5 | 11 | 22 | at NYR | L 2-3 | Toivonen | P. Bergeron, G. Murray |
| Nov 23,2005 | 23 | 8-10-5 | 11 | 20 | at TOR | W 5-1 | Raycroft | G. Murray [2], P. Bergeron, S. McEachern, S. Samsonov |
| Nov 25,2005 | 24 | 8-11-5 | 11 | 22 | vs PHI | L 3-5 | Raycroft | J. Slegr, E. Nickulas, J. Thornton |
| Nov 26,2005 | 25 | 8-12-5 | 11 | 22 | at OTT | L 2-4 | Raycroft | N. Boynton, B. Isbister |
| Nov 29,2005 | 26 | 8-13-5 | 12 | 23 | at NJ | L 2-3 | Raycroft | P. Bergeron, S. Samsonov |
| Date | Game# | Record | ConfRank | LgRank | Opp | Result | Goalie | Goals |
| Dec 1,2005 | 27 | 9-13-5 | 12 | 23 | vs OTT | W 3-0 | Toivonen | P. Bergeron, D. LaCouture, M. Sturm |
| Dec 3,2005 | 28 | 10-13-5 | 11 | 21 | at EDM | W 5-4 | Toivonen | B. Boyes [2], D. Tanabe, P. Bergeron, S. Samsonov |
| Dec 4,2005 | 29 | 10-14-5 | 11 | 21 | at VAN | L 2-5 | Toivonen | B. Isbister, M. Sturm |
| Dec 7,2005 | 30 | 10-15-5 | 11 | 22 | at COL | L 1-4 | Raycroft | M. Sturm |
| Dec 11,2005 | 31 | 10-15-6 | 12 | 25 | vs PHO | OTL 1-2 | Toivonen | B. Leetch |
| Dec 15,2005 | 32 | 11-15-6 | 12 | 24 | at MIN | W 3-2 | Raycroft | P. Bergeron, M. Sturm, S. Samsonov |
| Dec 17,2005 | 33 | 11-16-6 | 12 | 25 | at CGY | L 0-3 | Raycroft | |
| Dec 22,2005 | 34 | 12-16-6 | 12 | 24 | vs TOR | W 4-1 | Toivonen | T. Green, W. Primeau, A. Zhamnov, B. Stuart |
| Dec 23,2005 | 35 | 12-17-6 | 12 | 24 | at TOR | L 1-2 | Toivonen | S. Samsonov |
| Dec 27,2005 | 36 | 13-17-6 | 12 | 24 | at WAS | W 4-3 | Toivonen | G. Murray, M. Sturm, S. Samsonov, B. Stuart |
| Dec 28,2005 | 37 | 13-18-6 | 13 | 25 | at FLA | L 4-6 | Raycroft | B. Boyes [2], M. Sturm, P. Axelsson |
| Dec 30,2005 | 38 | 14-18-6 | 13 | 25 | at TB | W 2-1 | Toivonen | P. Bergeron, W. Primeau |
| Date | Game# | Record | ConfRank | LgRank | Opp | Result | Goalie | Goals |
| Jan 2,2006 | 39 | 14-19-6 | 13 | 25 | vs PHI | L 0-1 | Toivonen | |
| Date | Game# | Record | ConfRank | LgRank | Opp | Result | Goalie | Goals |
| Jan 5,2006 | 40 | 15-19-6 | 13 | 25 | vs OTT | W 4-2 | Toivonen | T. Green, G. Murray, B. Boyes, B. Stuart |
| Jan 7,2006 | 41 | 16-19-6 | 12 | 24 | vs TB | W 6-3 | Raycroft | M. Jurcina [2], P. Leahy, P. Bergeron, M. Sturm, P. Axelsson |
| Jan 10,2006 | 42 | 16-20-6 | 13 | 25 | vs SJ | L 2-6 | Raycroft | M. Jurcina [2] |
| Jan 12,2006 | 43 | 16-21-6 | 13 | 25 | vs LA | L 0-6 | Raycroft | |
| Jan 14,2006 | 44 | 16-21-7 | 13 | 25 | vs DAL | SOL 1-2 | Thomas | M. Jurcina |
| Jan 16,2006 | 45 | 17-21-7 | 12 | 24 | vs ANA | W 4-3 | Thomas | M. Sturm [2], P. Bergeron, S. Samsonov |
| Jan 19,2006 | 46 | 18-21-7 | 11 | 23 | at PHI | W 5-2 | Thomas | T. Green [2], P. Bergeron, W. Primeau, M. Sturm |
| Jan 21,2006 | 47 | 18-21-8 | 11 | 23 | vs NYR | SOL 2-3 | Thomas | M. Sturm, B. Stuart |
| Jan 23,2006 | 48 | 19-21-8 | 11 | 23 | at WAS | W 3-2 | Thomas | W. Primeau [2], B. Boyes |
| Jan 24,2006 | 49 | 20-21-8 | 11 | 23 | at ATL | W 3-2 | Thomas | M. Sturm, P. Axelsson, B. Stuart |
| Jan 26,2006 | 50 | 21-21-8 | 11 | 23 | vs WAS | W 3-2 | Thomas | E. Nickulas, B. Boyes, M. Sturm |
| Jan 28,2006 | 51 | 21-22-8 | 11 | 23 | vs NYI | L 3-4 | Thomas | P. Bergeron, B. Boyes, P. Axelsson |
| Jan 30,2006 | 52 | 22-22-8 | 10 | 22 | at OTT | W 5-0 | Thomas | N. Boynton, P. Bergeron, B. Boyes, M. Sturm, S. Samsonov |
| Date | Game# | Record | ConfRank | LgRank | Opp | Result | Goalie | Goals |
| Feb 2,2006 | 53 | 23-22-8 | 9 | 21 | vs MON | W 3-1 | Thomas | P. Bergeron, G. Murray, B. Boyes |
| Feb 4,2006 | 54 | 23-23-8 | 10 | 22 | at MON | L 0-2 | Thomas | |
| Feb 5,2006 | 55 | 23-23-9 | 10 | 22 | vs CAR | SOL 3-4 | Thomas | D. Tanabe, B. Boyes, B. Stuart |
| Feb 8,2006 | 56 | 24-23-9 | 10 | 22 | at PIT | W 3-1 | Thomas | B. Stuart [2], T. Green |
| Feb 9,2006 | 57 | 24-23-10 | 10 | 21 | vs NJ | OTL 2-3 | Thomas | G. Murray, W. Primeau |
| Feb 11,2006 | 58 | 24-24-10 | 10 | 22 | vs TB | L 5-6 | Thomas | P. Bergeron [2], D. LaCouture, G. Murray, T. Fitzgerald |
| Date | Game# | Record | ConfRank | LgRank | Opp | Result | Goalie | Goals |
| Mar 1,2006 | 59 | 24-25-10 | 11 | 23 | at CAR | L 3-4 | Thomas | D. Tanabe, S. Samsonov |
| Mar 2,2006 | 60 | 25-25-10 | 9 | 21 | vs ATL | W 3-2 | Raycroft | G. Murray, M. Sturm, T. Fitzgerald |
| Mar 4,2006 | 61 | 25-26-10 | 10 | 22 | vs BUF | L 2-3 | Raycroft | G. Murray, M. Sturm |
| Mar 7,2006 | 62 | 25-27-10 | 12 | 24 | at BUF | L 2-3 | Thomas | M. Jurcina, P. Bergeron |
| Mar 9,2006 | 63 | 25-28-10 | 12 | 24 | vs MON | L 0-3 | Thomas | |
| Mar 11,2006 | 64 | 25-29-10 | 13 | 25 | vs NYI | L 1-3 | Thomas | B. Leetch |
| Mar 12,2006 | 65 | 25-30-10 | 13 | 25 | at BUF | L 2-6 | Raycroft | A. Alberts, B. Boyes |
| Mar 14,2006 | 66 | 25-30-11 | 13 | 25 | at TOR | SOL 4-5 | Thomas | M. Sturm [2], M. Reasoner, G. Murray |
| Mar 16,2006 | 67 | 26-30-11 | 12 | 24 | vs OTT | W 3-2 | Thomas | P. Bergeron, B. Boyes |
| Mar 18,2006 | 68 | 27-30-11 | 13 | 25 | vs CAR | W 4-2 | Thomas | B. Boyes [3], P. Bergeron |
| Mar 20,2006 | 69 | 27-31-11 | 13 | 25 | at NYR | L 2-5 | Thomas | B. Boyes, H. Gill |
| Mar 21,2006 | 70 | 27-31-12 | 13 | 25 | vs ATL | SOL 4-5 | Thomas | P. Bergeron, M. Czerkawski, G. Murray, M. Sturm |
| Mar 24,2006 | 71 | 27-32-12 | 13 | 25 | at NJ | L 2-4 | Raycroft | G. Murray, B. Isbister |
| Mar 25,2006 | 72 | 28-32-12 | 13 | 25 | vs BUF | W 5-4 | Thomas | P. Bergeron, G. Murray, B. Boyes, M. Sturm, T. Fitzgerald |
| Mar 27,2006 | 73 | 28-32-13 | 13 | 25 | vs FLA | SOL 3-4 | Thomas | P. Bergeron [2], B. Boyes |
| Mar 29,2006 | 74 | 28-33-13 | 13 | 25 | at BUF | L 3-4 | Thomas | D. Tanabe, M. Reasoner, B. Stuart |
| Date | Game# | Record | ConfRank | LgRank | Opp | Result | Goalie | Goals |
| Apr 1,2006 | 75 | 28-34-13 | 13 | 25 | at MON | L 0-2 | Thomas | |
| Date | Game# | Record | ConfRank | LgRank | Opp | Result | Goalie | Goals |
| Apr 4,2006 | 76 | 28-35-13 | 13 | 25 | at MON | L 3-5 | Thomas | P. Bergeron [2], M. Sturm |
| Apr 6,2006 | 77 | 29-35-13 | 13 | 25 | vs TOR | W 3-2 | Thomas | M. Czerkawski, G. Murray |
| Apr 8,2006 | 78 | 29-35-14 | 13 | 25 | vs NYR | OTL 3-4 | Thomas | B. Boyes [2], M. Czerkawski |
| Apr 10,2006 | 79 | 29-35-15 | 13 | 25 | vs WAS | OTL 1-2 | Thomas | M. Stuart |
| Apr 11,2006 | 80 | 29-35-16 | 13 | 25 | at OTT | OTL 3-4 | Thomas | T. Green, P. Bergeron, B. Stuart |
| Apr 13,2006 | 81 | 29-36-16 | 13 | 25 | vs MON | L 3-4 | Thomas | P. Bergeron [2], Y. Stastny |
| Apr 15,2006 | 82 | 29-37-16 | 13 | 25 | at ATL | L 3-4 | Thomas | T. Green, M. Czerkawski, M. Sturm |
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